ANTI-HYPERLIPIDEMIC POTENTIAL OF VITEX DONIANAETHANOLEXTRACTS ON POLOXAMER 407 INDUCED HYPERLIPIDEMIC AND NORMAL RATS
- Project Research
- 1-5 Chapters
- Abstract : Available
- Table of Content: Available
- Reference Style: APA
- Recommended for : Student Researchers
- NGN 3000
ABSTRACT
Anti-hyperlipidemic potential of extracts (aqueous, 70% methanol, 70% ethanol and 70%, acetone) of Vitexdoniana leaves, stem bark and root bark on poloxamer 407 induced hyperlipidemic and normal rats was investigated. Phytochemical screening of the extracts revealed the presence of flavonoids, saponins, cardiac glycosides, alkaloids and tannins in the leaves, stem bark and root bark. The average total polyphenol contents of the leaves ethanol (36.11±3.13mg/g gallic acid) and methanol (35.75±1.72mg/g gallic acid) extracts were significantly (p0.05) change between normal control rats and normal treated rats in lipid profile parameters and atherogenic indices. The level viii of liver marker enzymes (ALT, ALP, AST) and liver function parameter (TB, IB) were significantly (p<0.05)higher, and lower (TB, DB) in hyperlipidemic control groups compared to all other groups. The invivo antioxidant activity shows a significantly (p<0.05) higher level of TBARS and a significant (p<0.05) lower level of SOD and CAT in hyperlipidemic groups when compared to all treated groups. In both liver and kidney, the leaves and stem bark extract significantly (p<0.05) lowers levels of TBARS of normal control rats compared to normal treated and all induced treated groups. All the extractsactivity in the liver and leaves extract in the kidney of normal rats show a significant higher level of CAT compared with other treated groups. The study shows that vitexdonianapossesses anti-hyperlipidemic potential.
Related Project Materials
EXCHANGE RATE DYNAMICS AND THE BALANCE OF PAYMENTS IN SIERRA LEONE
ABSTRACT
There is a strong relationship between exchange rate movements and the Balance of Payments (BoP). In Sierra Leone, exchange rate...
PRINT MEDIA AS ELECTIONEERING TOOL IN NIGERIA GOVERNORSHIP ELECTION
Background of the study
Unquestionably, media is a potent and swift mode of communication. It has a sig...
A System of Automated Web Service Selection
Abstract
In the modern world, service oriented applications are becoming more and more popular from year to year. To remain competitive,...
THE INFLUENCE OF ONLINE MARKETING ON RESIDENTIAL REAL ESTATE MARKET
BACKGROUND OF THE STUDY
These days, a significant portion of commercial business all around the world t...
THE IMPACT OF DEBT FINANCING ON FINANCIAL PERFORMANCE OF MANUFACTURING FIRMS IN NIGERIA
ABSTRACT
Debt financing decision is among the key financial decisions that are taken b...
THE SOCIAL EFFECT OF ADVERTISING ON THE NIGERIAN STUDENTS
EXCERPT FROM THE STUDY
Advertisers have found their recess with teenagers. They have become very creative when it comes...
SPECTROPHOTOMETRIC DETERMINATION AND STABILITY STUDIES OF ARTEMETHER IN ARTEMETHER-LUMEFANTRINE SUSPENSIONS MARKETTED IN NIGERIA
ABSTRACT
The increasing use of artemether-lumefantrine combination as an effective treatment for resistant malaria demands the need for a...
ANTICONVULSANT STUDIES OF THE METHANOL EXTRACT AND FRACTIONS OF CASSIA SIAMEA LAM. (FABACEAE) IN MICE AND CHICKS
ABSTRACT
Cassia siamea is a shrub belonging to the Fabaceae family, native of Southeast Asia. The plant is commonly used in traditional m...
ASSESSMENT OF TOURISM CONTRIBUTIONS TO THE SOCIOECONOMIC DEVELOPMENT OF NIGERIA (A CASE STUDY OF OSUN STATE)
Background of Study
The United Nations of World Tourism Organization defines tourism as the activ...
CONSTRUCTION OF A LIGHT SENSITIVE ALARM
ABSTRACT
This write up is concerned with the construction of a light sensitive alarm. The light sensitive alarm is a...
